Three new oblongolides from Phomopsis sp. XZ-01, an endophytic fungus from Camptotheca acuminate.

نویسندگان

  • Ting Lin
  • Guang Hui Wang
  • Xiang Lin
  • Zhi Yu Hu
  • Quan Cheng Chen
  • Yang Xu
  • Xiao Kun Zhang
  • Hai Feng Chen
چکیده

Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds--oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12)--were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including 1H- and 13C-NMR, 2D NMR (HSQC, HMBC, 1H-1H COSY and NOESY) and HR-FT-MS. Cytotoxic activities of these compounds were evaluated. Some of them showed weak selective activities.

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عنوان ژورنال:
  • Molecules

دوره 16 4  شماره 

صفحات  -

تاریخ انتشار 2011